Willi Castro had the game-ending sacrifice fly with the bases loaded in the ninth, lifting the Twins to a 7-6 comeback victory over the Cleveland Guardians on Thursday night.
Bailey Ober allowed one run in six innings, Kyle Farmer homered and drove in three runs, and the Minnesota Twins beat Los Angeles 5-1 on Tuesday night.
Ryan (5-0) joined Jerry Koosman in 1979 as the only Twins pitchers to win their first five starts since the franchise moved to Minnesota for the 1961 season.
Umpires needed a few minutes to review Verdugo's drive, which bounced off the low wall in right field just short of Pesky's Pole, before officially declaring it a hit and the game over.
Minnesota, which had lost 13 of its previous 16 games against the Yankees, had its highest-scoring inning against New York in a top of the first that took 28 minutes.
Currently on a minor league deal with the Minnesota Twins, his sixth team, De Leon carved through the lineup that included veteran outfielder Joc Pederson.
Twins manager Rocco Baldelli said the PitchCom device catcher Tony Wolters was using was loud enough for Tampa Bay Rays hitters to hear every pitch that was called.