Mayo Clinic Net Income Exceeded $1.5 Billion in 2025

Rochester, MN (KROC-AM News) - Mayo Clinic is reporting that a key indicator of its financial performance rose by more than $100 million in 2025.

A required financial filing with the Municipal Securities Rulemaking Board shows Mayo Clinic's net income from current activities, which would equate to "profit" if it were not a nonprofit institution, reached $1.508 billion last year without donor restrictions. At the end of 2024, that figure was just over $1.4 billion.

"Guided by our primary value of putting the needs of our patients first, 2025 was another strong year for Mayo Clinic," said Gianrico Farrugia, M.D., president and CEO. "Through our Bold. Forward. strategy, we delivered new capabilities that meaningfully improved patients’ lives and positioned us to accelerate patient-centered transformation in the year ahead."

Revenues Rose 8.2%

Mayo Clinic's overall revenue without donor restrictions in 2025 was $21.556 billion. That represents an increase of 8.2%, or more than $1.65 billion, compared to the previous year. Revenue from providing medical services totaled more than $18.1 billion. That figure was up nearly 9.5% from 2024.

Expenses Up 8.4%

Mayo Clinic reported that its overall expenses last year rose by about 8.4% to just over $20 billion. The health care provider's largest expense, salaries and benefits, increased by more than 6.4% to about $11.16 billion, while its supply and services expenses jumped 9.7% to a little under $7.5 billion.

Mayo Clinic also announced that its workforce increased by 12,400 people in 2025. The organization now has nearly 85,000 employees.

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With the $5 billion Bold. Forward. Unbound. initiative just getting underway in 2025, Mayo Clinic's facilities expenses were higher, but not dramatically higher, compared to 2024. The filing shows that Mayo Clinic listed $456 million in facilities expenses, while the total from the previous year was $415 million.

Investment Returns More Than Doubled

The report shows that Mayo Clinic's investments performed well in 2025, with an overall return, without donor restrictions, of nearly $1.98 billion. The return on investments in 2024 was around $960 million.

The report was filed with the online Electronic Municipal Market Access site, a service of the Municipal Securities Rulemaking Board. The report is required because of municipal bonds sold by Mayo to finance various economic development projects.