JERUSALEM (AP) -- Two Palestinian cousins armed with meat cleavers and a gun stormed a Jerusalem synagogue during morning prayers Tuesday, killing four people in the city's bloodiest attack in years. Police killed the attackers in a shootout.

The attack ratcheted up fears of sustained violence in the city, which is already on edge amid soaring tensions over its most contested holy site.

Police said the dead worshippers were three Americans and a Briton, and that all held dual Israeli citizenship. The attack occurred in Har Nof, an ultra-Orthodox neighborhood that has a large population of English-speaking immigrants.

Prime Minister Benjamin Netanyahu vowed to "respond harshly," describing the attack as a "cruel murder of Jews who came to pray and were killed by despicable murderers."

The U.S. Consulate in Jerusalem identified the Americans as Aryeh Kupinsky, Cary William Levine and Mosheh Twersky.

Twersky, the grandson of a renowned rabbi from Boston, Joseph Soloveichik, was the head of Yeshivas Toras Moshe, a religious seminary for English-speaking students.

Israeli authorities identified the British man as Avraham Goldberg.

One Canadian was wounded in the attack, said Francois Lasalle, a spokesman for Canada's Foreign Affairs Department. He declined to provide further details.

U.S. Secretary of State John Kerry said he spoke to Netanyahu after the assault and denounced it as an "act of pure terror and senseless brutality and violence."

Palestinian President Mahmoud Abbas condemned the attack, the first time he has done so since a recent spike in deadly violence against Israelis. He also called for an end to Israeli "provocations" surrounding a sacred shrine holy to both Jews and Muslims.

The attack was the deadliest in Jerusalem since a Palestinian assailant killed eight students at a Jewish seminar in March 2008.

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