Rochester, MN (KROC-AM News) - After reporting record financial results for 2024, Mayo Clinic is reporting strong numbers for the first three months of this year.

A required federal regulatory filing shows the healthcare giant's income from current activities from January through March totaled $359 million. The figure, which is considered a key measure of Mayo's financial performance, was up about 5%, or $18 million, when compared to the first quarter of last year.

The Revenue Total Exceeded $5 Billion For the Three Month Period

The report to the Municipal Securities Rulemaking Board indicates Mayo Clinic's quarterly revenues climbed to nearly $5.1 billion. The revenue total came in $376 million, or nearly 8%, above the revenues from the first three months of 2024.

Kim David/TSM

Mayo Clinic reported expenses that slightly outpaced revenues in the first quarter. Overall expenses were up $358 million, or 8.1%, at a little over $4.73 billion. Mayo's single largest expense category is salaries and benefits. They increased by about $113 million, or 4.3%, to around $2.68 billion.

ALSO SEE: Mayo Clinic 2024 “Profit” Hit Record High of Nearly $1.3 Billion

The regulatory filing also shows the turbulence on Wall Street had a significant impact on Mayo Clinic's finances. After reporting $433 million from investment returns in the first quarter of last year, Mayo indicated that it incurred a $43 million loss for the first three months of 2025.

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The unaudited report was filed with the online Electronic Municipal Market Access site, a service of the Municipal Securities Rulemaking Board. The report is required because of municipal bonds sold by Mayo to finance various economic development projects.